Search on: PYROGLUTAMYL-PEPTIDASE I 
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Descriptor English:   Pyroglutamyl-Peptidase I 
Descriptor Spanish:   Piroglutamil-Peptidasa I 
Descriptor Portuguese:   Piroglutamil-Peptidase I 
Synonyms English:   Pyroglutamate Aminopeptidase
Pyrrolidonecarboxylate Peptidase
Pyrrolidonyl Peptidase
5-Oxoprolyl-Peptidase  
Tree Number:   D08.811.277.656.350.100.755
Definition English:   An enzyme that catalyzes the release of a N-terminal pyroglutamyl group from a polypeptide provided the next residue is not proline. It is inhibited by thiol-blocking reagents and occurs in mammalian tissues, microorganisms, and plants. (From Enzyme Nomenclature, 1992) EC 3.4.19.3. 
History Note English:   95: was 5-OXOPROLYL-PEPTIDASE 1991-94; was PYROGLUTAMATE AMINOPEPTIDASE see under AMINOPEPTIDASES 1975-90 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
CT contraindications DF deficiency
DU diagnostic use DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   29282 
Unique Identifier:   D011751 

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